Transmission of Antibiotic Resistant Enterobacteriaceae between Animals and Humans Gastrointestinal Tract with the Evidence of in vivo Plasmid Transfer

Karwan MAHMOOD, Emel Banu BÜYÜKÜNAL BAL
6.775 517

Öz


Esas tartışma konusu olan nokta, bakteri ve plazmit kaynaklı bakteri direncinin hayvanlardan insanlara nasılgeçebileceğidir. Antibiyotiklerin çiftlik hayvanlarında kullanımı daha önceleri dirençli bakterilerin tedavi görmüşhayvanlarda ve insanlarda varlığını göstermiştir (hayvan bakıcıları ve çiftlik çalışanları). Direncin geçişininhayvanlardan insanlara doğru olabileceği şeklinde kanıtlar bulunmaktadır. Bu kanıtların çoğu, direkt olmamakla birliktehayvanlardan (çiftlik hayvanları) ve bunlarla temas halindeki insanlardan (hayvan bakıcıları ve çiftlik çalışanları) izoleedilen bakteriler arasındaki direnç profillerinin benzerliklerine dayanmaktadır. Direkt kanıtlar, birbirleriyle klonal ilişkiliinsan ve hayvan kaynaklı dirençli zoonotik bakterilerin veya yine bunlardaki dirençle ilgili plazmitlerin molekülermetotlara dayalı olarak saptanması ile olmuştur.

Anahtar kelimeler


Enterobacteriaceae, β-laktamaz, E. coli, CTX-M

Tam metin:

PDF (English)


DOI: http://dx.doi.org/10.18016/ksujns.71116

Referanslar


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